2 edition of HLA in Health and Disease, Second Edition found in the catalog.
May 15, 2000
by Academic Press
Written in English
|Contributions||Robert Lechler (Editor), Anthony Warrens (Editor)|
|The Physical Object|
|Number of Pages||472|
A comprehensive guide to the HLA (Human Leukocyte Antigen) system for immunologists and clinicians, this book contains up-to-date information on the MHC (Major Histocompatibility Complex) and its role in the immune response and in various diseases. The book explores the biological significance and role of the HLA system in organ and . They discuss the history of HLA and its latest nomenclature, the biological significance of minor histocompatibility antigens, and the killer immunoglobulin-like receptors in health, disease, and transplantation, along with a section on disease associations, especially autoimmune, mycobacterial, and rheumatological diseases.
a) Diagrammatic representation of the HLA region on chromosome 6p21, b) More detailed diagrams of common AID genes within the HLA class I and class II region c) Representation of endogenous antigen presentation by HLA class I classical molecules (including HLA-A, -B and –C).Endogenous antigen generated in the cytosol is degraded within the proteasomes and Cited by: HLA-A is a group of human leukocyte antigens (HLA) that are coded for by the HLA-A locus, which is located at human chromosome 6p HLA is a major histocompatibility complex (MHC) antigen specific to humans. HLA-A is one of three major types of human MHC class I cell surface others are HLA-B and HLA-C. The receptor is a heterodimer, and is composed Protein type: Cell surface receptor.
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The second section deals with the importance of HLA in the context of different clinical specialities. Individual chapters describe the association between HLA polymorphism and each disease. The final section features chapters on current laboratory practice in histocompatibility and tissue typing.
HLA in Health and Disease is essential reading Author: Robert Lechler. Purchase HLA in Health and Disease - 2nd Edition. Print Book & E-Book. ISBNBook Edition: 2. The second section deals with the importance of HLA in the context of different clinical specialities. Individual chapters describe the association between HLA polymorphism and each disease.
The final section features chapters on current laboratory practice in histocompatibility and tissue typing. HLA in Health and Disease is essential reading Price Range: $ - $ The HLA FactsBook presents up-to-date and comprehensive information on the HLA genes. Fourteen introductory chapters provide an invaluable guide to the basic structure, function and genetics of the HLA genes, as well as to the nomenclature and methods used for HLA by: HLA in Health and Disease is essential reading for basic and clinical researchers working in immunology and immunogenetics, transplantation medicine and autoimmunity.
It will also be of interest to anyone in the fields of rheumatology, diabetology, nephrology, allergy, dermatology, neurology, endocrinology, cancer biology, respiratory medicine.
This comprehensive and definitive work succeeds and expands on the highly successful HLA and Disease published in This new edition has been updated, redesigned and reorganised into three sections making it an invaluable reference. The introductory section summarises current knowledge on the structure, function, genetics and evolution of the.
Get this from a library. HLA in health and disease. [Robert Lechler; Anthony N Warrens;] -- "The introductory section summarises current knowledge on the structure, function, genetics and evolution of the HLA system.
It clarifies its complex and ever changing nomenclature and discusses the. Fifty years since the first description of an association between HLA and human disease, HLA molecules have proven to be central to physiology, protective immunity and deleterious, disease-causing Cited by: The second section deals with the importance of HLA in the context of different clinical specialities.
Individual chapters describe the association between HLA polymorphism and each disease. The final section features chapters on current laboratory practice in histocompatibility and tissue typing. HLA in Health and Disease is essential reading. HLA and Disease Yogita et ability of health care and environmental factors such.
as nutrition, coincident microbial and parasitic most patients inheriting HLA-B Second, inheri. Paul Brogan, Arvind Bagga, in Textbook of Pediatric Rheumatology (Seventh Edition), Genetic Background.
Familial clusters of the disease may occur, with siblings affected simultaneously or sequentially. 19,56,57 Investigations from Spain have presented preliminary data on genetic associations. The frequency of human leukocyte antigen (HLA)-B35 was.
The human leukocyte antigen (HLA) system or complex is a group of related proteins that are encoded by major histocompatibility complex (MHC) gene complex in human. These cell-surface proteins are responsible for the regulation of the immune system in humans. The HLA gene complex resides on a 3 Mbp stretch within chromosome 6p HLA genes are highly InterPro: IPR Alan M.
Rosenberg, Kiem G. Oen, in Textbook of Pediatric Rheumatology (Seventh Edition), Non-HLA Genes. HLA-DR alone accounts for 17 % of the genetic risk for juvenile rheumatoid arthritis (JRA) and provides the greatest risk with odds ratios (OR) ranging from 3 to Moreover, HLA associations are specific for JRA or JIA subtypes.
In contrast. HLA in Health and Disease fills this gap in an approachable and well-structured way. Significantly expanded from the first edition, the new edition of HLA in Health and Disease addresses the subject in three major sections, on the biology of the HLA system, HLA and disease association, and methods of HLA : Michael Browning.
There is clustering of cases in certain families who have a genetically changed cell surface antigen, called “HLA-B27” and “HLA-B7” (Ref. 2) that is found on white blood cells in patients with ankylosing spondylitis.
Also, males are about 2 1/2 times. HLA-DR is an MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p The complex of HLA-DR (Human Leukocyte Antigen – DR isotype) and peptide, generally between 9 and 30 amino acids in length, constitutes a ligand for the T-cell receptor (TCR).HLA (human leukocyte antigens) were originally defined as Protein type: cell surface receptor.
The Michael Mason Prize Essay. Although the strong association of possession of the human leucocyte antigen HLA B27 with the spondyloarthropathies (Table 1) has been recognized for over 25 yr , the pathogenic link remains us hypotheses have been proposed to explain the association of HLA B27 with spondyloarthritis, and are Cited by: American Trypanosomiasis, Chagas Disease: One Hundred Years of Research, Second Edition, provides a comprehensive overview of Chagas disease and discusses the latest discoveries concerning the three elements that compose the transmission chain of the disease, the host, the insect vectors, and the causative parasite.
In addition, new insights on the molecular biology. Fourteen introductory chapters provide a beginner's guide to the basic structure, function, and genetics of the HLA genes, as well as to the nomenclature and methods used for HLA typing.
This book will be an invaluable reference for researchers studying the human immune response, for clinicians and laboratory personnel involved in clinical and. Back to Index 1. HLA- disease associations and transplantation 1. Review of the function and polymorphisms of HLA molecules Figure The distribution of the main genes that encode MHC class I and MHC class II molecules on the short arm of chromosome 6; the figure also shows the large number of allelic forms of most of these Size: KB.
Description. Part of the highly regarded Diagnostic Pathology series, this updated volume by Drs. Anthony Chang and Robert B. Colvin is an ideal point-of-care reference to guide you through the complex realm of transplant e, focused chapters, supported by tables, diagrams, radiographs, and photographs, provide essential information to keep you up to date with the .The transplantation of tissues to replace diseased organs is now an important medical therapy.
In most cases, adaptive immune responses to the grafted tissues are the major impediment to successful transplantation. Rejection is caused by immune responses to alloantigens on the graft, which are proteins that vary from individual to individual within a species, and are thus Cited by: 6.Rheumatoid arthritis is a common polyarthritis that can affect any joint.
Notably, it is an autoimmune disease, where the synovial membranes of joints experience chronic inflammation. Eventually the ligaments and the cartilage experience destruction resulting in joint stiffness, severe disability and premature death.